Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells
نویسندگان
چکیده
منابع مشابه
Duodenal acidification stimulates gastric H2S release through upregulating mRNA expression of cystathionine gamma lyase
Introduction: It has been reported the alkaline response of pancreas to duodenal acidification is partly mediated through duodenal release of H2S, but till now the effect of duodenal acidification on gastric H2S release has not been investigated. Therefore, the present study designed to evaluate the effects of duodenal acidification on gastric H2S release and level of mRNA expression of cys...
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Cystathionine gamma-lyase of Saccharomyces cerevisiae was immobilized to aminohexyl-Sepharose through the cofactor pyridoxal 5'-phosphate and was characterized with respect to its cystathionine gamma-synthase activity. The immobilized product was so stable that it repeatedly catalyzed as many as five cycles of the reaction without losing activity.
متن کاملRegulation of cystathionine gamma-lyase/H₂S system and its pathological implication.
Hydrogen sulfide (H2S) is a highly diffusible gasotransmitter, that influence cellular and organ functions by a number of different mechanisms. Cystathionine gamma-lyase (CSE) is one major H2S-producing enzyme with L-cysteine as the main substrate in mammalian cells. Since the discovery of endogenously-produced H2S as a biological mediator, there has been an explosion of interest in CSE express...
متن کاملEffect of cysteine on the inactivation of cystathionine gamma-lyase by D,L-propargylglycine.
In vivo inactivation of cystathionine gamma-lyase by D,L-propargylglycine, a suicide inhibitor, was found to be less profound in rat kidney than in the liver. We investigated the cause of this difference using rat tissues. We fractionated kidney extract to characterize the substance which protected enzyme, and found that cysteine exhibits protecting action. Addition of 0.3 mM L-cysteine to the ...
متن کاملCystathionine gamma-lyase of perivascular adipose tissue with reversed regulatory effect in diabetic rat artery
The aim of this study is to reveal the regulatory role of cystathionine gamma-lyase (CSE), the main source of hydrogen sulphide (H2S) in perivascular adipose tissue (PVAT), of diabetic rats. Diabetes was induced in male rats by a single intraperitoneal injection of streptozotocin. Animals with glucose levels above 20 mmol/L were determined as diabetic. The rat gracilis arteries (a. gracilis) we...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2010
ISSN: 1755-3245,0008-6363
DOI: 10.1093/cvr/cvp420